Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Arkaitz Carracedo, Li Ma, Julie Teruya‐Feldstein, +12

Journal of Clinical Investigation

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar, Laura N. Burga, Hai Hu, +14

Cancer Discovery

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Pengda Liu, Michael J. Begley, Wojciech Michowski, +22

Nature

Signal TransductionCell RegulationBiochemistryCarboxyl TerminusNatural Sciences +11

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Yu-Ru Lee, Ming Chen, Jonathan D. Lee, +24

Science

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

Antonella Papa, Lixin Wan, Massimo Bonora, +16

Cell

Signal TransductionSignaling PathwayCell RegulationMedicineDominant-negative Manner +7

Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors

Robin M. Hobbs, Sharmila Fagoonee, Antonella Papa, +5

Cell stem cell

GeneticsGenetic MechanismMolecular GeneticsGermline GeneticsGerm Cell Development +5

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Jlenia Guarnerio, Yang Zhang, Giulia Cheloni, +17

Cell Research

Intragenic Antagonistic RolesLong Non-coding RnaSmall RnaMedicineCell Biology +2

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

Lisa M. Ooms, Lauren C. Binge, Elizabeth M. Davies, +14

Cancer Cell

Tumor BiologySignaling PathwayMedicineCancer Cell BiologyProtein Phosphorylation +7

<i>In Vivo</i> Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes

Chen Li Chew, Andrea Lunardi, Federico Gulluni, +13

Cancer Discovery

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the<i>TRKA</i>and<i>p75NTR</i>Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Nunzio Iraci, Daniel Diolaiti, Antonella Papa, +8

Cancer Research

Aggressive Mycn-amplified TumorsTranscriptional RegulationCell RegulationAffects Neuroblastoma MalignancyMedicine +12