The Lab Oddity Prevails: Discovery of Pan‐CDK Inhibitor (<i>R</i>)‐<i>S</i>‐Cyclopropyl‐<i>S</i>‐(4‐{[4‐{[(1<i>R</i>,2<i>R</i>)‐2‐hydroxy‐1‐methylpropyl]oxy}‐5‐(trifluoromethyl)pyrimidin‐2‐yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

Ulrich Lücking, Rolf Jautelat, Martin Krüger, +9

ChemMedChem

Aminopyrimidine Zk 304709Lab Oddity PrevailsLead IdentificationBay 1000394Zk 304709 +19

Intra- and intermolecular hetero-Diels-Alder reactions. 17. Intramolecular hetero-Diels-Alder reaction of alkylidene- and benzylidenepyrazolones and benzylideneisoxazolones. Investigations toward the conformation of the transition state

Lutz F. Tietze, Thomas Brumby, M. PRETOR, +1

The Journal of Organic Chemistry

Transition StateEngineeringHeterocyclicDonut IconAltmetric Attention Score +11

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

Erik Eggert, R.C. Hillig, Silke Koehr, +21

Journal of Medicinal Chemistry

Histone ModificationsDrug TargetEpigenetic ChangeMolecular BiologyProtein Methylation +17

From the Insoluble Dye Indirubin towards Highly Active, Soluble CDK2‐Inhibitors

Rolf Jautelat, Thomas Brumby, Martina Schäfer, +7

ChemBioChem

Pharmaceutical ScienceCancer BiologyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +15

Intra- and intermolecular hetero-Diels-Alder reactions. 45. Simple and induced diastereoselectivity in intramolecular hetero-Diels-Alder reactions of 1-oxa-1,3-butadienes. Experimental data and calculations

Lutz F. Tietze, Jens Fennen, Thomas Brumby, +2

The Journal of Organic Chemistry

Chemical EngineeringEngineeringHeterocyclicBiochemistryAlkene Metathesis +9

Intramolecular Hetero‐Diels–Alder Reactions of Oxadienes: Influence of Substituents of the Tether on the Diastereoselectivity

Lutz F. Tietze, Siegbert Brand, Thomas Brumby, +1

Angewandte Chemie International Edition in English

Control of the Conformation of Transition States in Intramolecular Diels‐Alder Reactions with Inverse Electron Demand

Lutz‐F. Tietze, Hartmut Stegelmeier, Klaus Harms, +1

Angewandte Chemie International Edition in English

Transition StatesIntramolecular Diels‐alder ReactionsEngineeringInverse Electron DemandNatural Sciences +7

Inter‐ and intramolecular <i>hetero</i> diels‐alder reactions, XXI. Intramolecular <i>hetero</i> diels‐alder reaction of alkylidene‐1,3‐dicarbonyl compounds. Experimental evidence for an asymmetric transition state

Lutz F. Tietze, Thomas Brumby, Siegbert Brand, +1

Chemische Berichte

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Sina Haftchenary, Shawn D. Nelson, Laura Furst, +13

ACS Combinatorial Science

Intra‐ and intermolecular <i>hetero</i> Diels‐Alder Reactions. XIX. Stereoselective synthesis of five‐ and seven‐membered annulated ring systems by intramolecular <i>hetero</i> Diels‐Alder Reaction

Lutz F. Tietze, Thomas Brumby, Thomas Pfeiffer

Liebigs Annalen der Chemie

High YieldsDerivativesEngineeringHeterocyclicNatural Sciences +9