Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

Markus Follmann, Jens Ackerstaff, Gorden Redlich, +21

Journal of Medicinal Chemistry

Medicinal ChemistryHeart FailureChronic Heart FailureCardiomyopathyCardiovascular Disease +13

The Lab Oddity Prevails: Discovery of Pan‐CDK Inhibitor (<i>R</i>)‐<i>S</i>‐Cyclopropyl‐<i>S</i>‐(4‐{[4‐{[(1<i>R</i>,2<i>R</i>)‐2‐hydroxy‐1‐methylpropyl]oxy}‐5‐(trifluoromethyl)pyrimidin‐2‐yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

Ulrich Lücking, Rolf Jautelat, Martin Krüger, +9

ChemMedChem

Aminopyrimidine Zk 304709Lab Oddity PrevailsLead IdentificationBay 1000394Zk 304709 +19

From the Insoluble Dye Indirubin towards Highly Active, Soluble CDK2‐Inhibitors

Rolf Jautelat, Thomas Brumby, Martina Schäfer, +7

ChemBioChem

Pharmaceutical ScienceCancer BiologyPharmaceutical ChemistryTumor BiologyMolecular Pharmacology +15

Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors

Anette Sommer, Charlotte Kopitz, Christoph A. Schatz, +18

Cancer Research

PathologyTumor BiologyPreclinical EfficacyFibroblast Growth FactorFgfr2 Amplification +14

Directed Synthesis of Nonsymmetrical Bis‐Steroidal Pyrazines and the First Biologically Active Cephalostatin Analogues

Michael Drögemüller, Rolf Jautelat, Ekkehard Winterfeldt

Angewandte Chemie International Edition in English

Bioorganic ChemistryOrganic ChemistryChemistryChemical BiologyPharmaceutical Chemistry +14

Discovery of Rogaratinib (BAY 1163877): a pan‐FGFR Inhibitor

Marie-Pierre L. Collin, Mario Lobell, Walter Hübsch, +9

ChemMedChem

Medicinal Chemistry OptimizationPan‐fgfr InhibitorTumor BiologyMolecular PharmacologyMedicinal Chemistry +14

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Volker Schulze, Ulrich Klar, Dirk Kosemund, +26

Journal of Medicinal Chemistry

Macrocyclic Aminopyrimidines as Multitarget CDK and VEGF‐R Inhibitors with Potent Antiproliferative Activities

Ulrich Lücking, Gerhard Siemeister, Martina Schäfer, +4

ChemMedChem

Combinatorial ChemistryPharmacotherapyVegf‐r InhibitorsChemical BiologyAminopyrimidine Inhibitors +18

Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer

Jörg Willuda, Lars Lindén, Hans‐Georg Lerchen, +20

Molecular Cancer Therapeutics

Synthesis of Cephalostatin Analogues by Symmetrical and Non-Symmetrical Routes

Michael Drögemüller, Rolf Jautelat, Ulrich Scholz, +1

European Journal of Organic Chemistry

Medicinal ChemistryBioorganic ChemistryCentral PrecursorBiochemistryNatural Sciences +13