Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli, +20

Journal of Medicinal Chemistry

Antiviral DrugMedicinal ChemistryAntiviral Drug DevelopmentResistance Mutation (Virology)Biochemistry +14

Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors

Roberta Ettari, Emanuela Nizi, Maria Emilia Di Francesco, +7

Journal of Medicinal Chemistry

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Steven J. Harper, John A. McCauley, Michael T. Rudd, +32

ACS Medicinal Chemistry Letters

ImmunologyMolecular BiologyPharmacotherapyAntiviral DrugMedicinal Chemistry +17

Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors

Paola Pace, Maria Emilia Di Francesco, Cristina Gardelli, +15

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryInteresting CompoundsBiochemistry +13

Novel Peptidomimetics Containing a Vinyl Ester Moiety as Highly Potent and Selective Falcipain-2 Inhibitors

Roberta Ettari, Nicola Micale, Tanja Schirmeister, +6

Journal of Medicinal Chemistry

Discovery and Synthesis of HIV Integrase Inhibitors:  Development of Potent and Orally Bioavailable N-Methyl Pyrimidones

Cristina Gardelli, Emanuela Nizi, Ester Muraglia, +23

Journal of Medicinal Chemistry

Medicinal ChemistryInteresting CompoundsBiochemistryMedicineDrug Discovery +13

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase

Paola Pace, Emanuela Nizi, Barbara Pacini, +5

Bioorganic & Medicinal Chemistry Letters

Viral ReplicationActive Site InhibitorNatural SciencesAntiviral Drug DevelopmentMolecular Biology +5

Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Ester Muraglia, Olaf Kinzel, Cristina Gardelli, +15

Journal of Medicinal Chemistry

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

Roberta Ettari, Emanuela Nizi, Maria Emilia Di Francesco, +5

ChemMedChem

Discovery of a Selective Series of Inhibitors of <i>Plasmodium falciparum</i> HDACs

Jesus M. Ontoria, Giacomo Paonessa, Simona Ponzi, +19

ACS Medicinal Chemistry Letters

Antiparasitic AgentMalariaPharmacotherapyNew SeriesChemical Biology +15