PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, +12

Cell Reports

Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib

Takashi Emori, Michiko Kasahara, Shingo Sugahara, +5

European Journal of Pharmacology

ImmunologyImmune RegulationPathologyCell DeathInnate Immunity +23

Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis

Takashi Emori, Jun Hirose, Kotoko Ise, +12

The Journal of Immunology

The effects of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on T-cell-related cytokine production in vitro and in vivo

Satoshi Yamamoto, Shingo Sugahara, Ryo Naito, +4

European Journal of Pharmacology

InflammationCytokineT-cell-related Cytokine ProductionAutoimmune DiseaseT-regulatory Cell +9

Amelioration of collagen-induced arthritis in mice by a novel phosphodiesterase 7 and 4 dual inhibitor, YM-393059

Satoshi Yamamoto, Shingo Sugahara, Ken‐ichi Ikeda, +1

European Journal of Pharmacology

InflammationRheumatologyDual InhibitorAnti-inflammatoryRheumatoid Disorder +13

Comparison of Cedar Pollen-Induced Allergic Rhinitis in Passively and Actively Sensitized Guinea Pigs

Takeshi Nabe, Nobuaki Mizutani, Seiichi Osaki, +3

The Japanese Journal of Pharmacology

Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models

Satoshi Yamamoto, Shingo Sugahara, Ken‐ichi Ikeda, +1

European Journal of Pharmacology

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineImmunology +11

Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs

Shingo Sugahara, Takeshi Nabe, Nobuaki Mizutani, +2

European Journal of Pharmacology

AsthmaAnimal PhysiologyAllergic Nasal HyperresponsivenessAllergyGuinea Pigs +8

Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Kenna Shirasuna, Gerald Koelsch, Cynthia Seidel‐Dugan, +12

Cancer Treatment and Research Communications

Lit-LAMP-DNA-vaccine for shrimp allergy prevents anaphylactic symptoms in a murine model

Kaori Kubo, Shinobu Takeda, Masao Uchida, +5

International Immunopharmacology