Concepedia

PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara,

Cell Reports · 2022 · 125 citations · 28 references

DOIFull text

Open access

Concepts

Abstract

-EP2/EP4 signaling functions as the key regulatory node linking active inflammation and immunosuppression in TME, which can be targeted by EP2 and EP4 antagonists for cancer therapeutics.

References

28

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