CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

Jong‐Min Lee, Kevin Correia, Jacob M. Loupe, +35

Cell

Neurodegenerative DiseasesHuntington ’Genetic DisorderGeneticsDegenerative Disease +6

Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease

Branduff McAllister, James F. Gusella, G. Bernhard Landwehrmeyer, +8

Neurology

Genetic modifiers of Huntington disease differentially influence motor and cognitive domains

Jong‐Min Lee, Yuan Huang, Michael Orth, +25

The American Journal of Human Genetics

Genetic DisorderGeneticsHuntington DiseaseInfluence MotorGenetic Factor +6

Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset

Branduff McAllister, Jasmine Donaldson, Caroline S. Binda, +21

Nature Neuroscience

Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease

Natalie Ellis, Amelia Tee, Branduff McAllister, +38

Biological Psychiatry

Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

S. V. Lobanov, Branduff McAllister, Mia McDade‐Kumar, +3

npj Genomic Medicine

Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing

Alysha Taylor, Dinis Barros, Nastassia Gobet, +17

NAR Genomics and Bioinformatics

GeneticsGenetic EpidemiologyMolecular BiologyMolecular GeneticsGenomics +23

Huntington’s disease onset is determined by length of uninterrupted CAG, not encoded polyglutamine, and is modified by DNA maintenance mechanisms

Jong‐Min Lee, Kevin Correia, Jacob M. Loupe, +35

GeneticsGenetic EpidemiologyMolecular BiologyDisease OnsetMolecular Genetics +24

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Nina Stöberl, Jasmine Donaldson, Caroline S. Binda, +5

Scientific Reports

Modification of Huntington’s disease by short tandem repeats

Eun Pyo Hong, Eliana Marisa Ramos, N. Ahmad Aziz, +18

Brain Communications