Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B

Jang‐June Park, David Wong, Abdus S. Wahed, +46

Gastroenterology

Viral PersistenceAutoimmune DiseaseHepatologyViral HepatitisGlobal T-cell Dysfunction +10

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

Yue J. Wang, Daniel Traum, Jonathan Schug, +8

Cell Metabolism

Type 1Human Endocrine PancreasAutoimmune DiseaseDiabetesImmunology +6

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Rajasekharan Somasundaram, Thomas Connelly, Robin Choi, +54

Nature Communications

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Maria Fasolino, Gregory W. Schwartz, Abhijeet R. Patil, +45

Nature Metabolism

Type 1Signal TransductionSingle-cell Multi-omics AnalysisMedicineDiabetes +10

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

Yue J. Wang, Maria L. Golson, Jonathan Schug, +9

Cell Metabolism

Human Endocrine PancreasPancreatic CancerSingle-cell BiologyEndocrinologyMedicine +2

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

Amin Abedini, Jonathan Levinsohn, Konstantin A. Klötzer, +27

Nature Genetics

Renal FunctionRenal DiseaseHuman KidneysSingle Cell SequencingMedicine +13

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

Michelle L. Hastings, Nicoletta Resta, Daniel Traum, +3

Nature Structural & Molecular Biology

Genetic DisorderNatural SciencesGeneticsMolecular BiologyPeutz-jeghers Syndrome +5

α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals

Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, +15

Journal of Clinical Investigation

ImmunologyInsulin SignalingType 1Cell SignalingAutoimmune Disease +17

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

Minghui Wu, Michelle Y. Y. Lee, Varun Bahl, +6

Cell Reports

Highly Multiplexed Image Analysis of Intestinal Tissue Sections in Patients With Inflammatory Bowel Disease

Ayano Kondo, Siyuan Ma, Michelle Y. Y. Lee, +7

Gastroenterology

EngineeringMedical ImagingIntestinal Tissue SectionsBioimage AnalysisDigital Pathology +11