Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

Frédéric Luciano, Arnaud Jacquel, Pascal Colosetti, +4

Oncogene

Protein FunctionSignal TransductionBiochemistryMedicineSerine 69 +9

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis

Benjamin Bian, Sébastien Mongrain, Sébastien Cagnol, +6

Molecular Carcinogenesis

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

Étienne Lemieux, Sébastien Cagnol, Katia Beaudry, +2

Oncogene

PathologyCancer BiologyWnt/β-catenin PathwayTumor BiologyTranscriptional Regulation +16

Oncogenic BRAF^V600E inhibits BIM expression to promote melanoma cell survival

Robert A Cartlidge, G. Ruth Thomas, Sébastien Cagnol, +4

Pigment Cell & Melanoma Research

Systems BiologySignal TransductionCell RegulationHuman MelanomaMedicine +13

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

Sébastien Bergeron, Étienne Lemieux, Véronique Durand, +5

Molecular Cancer

Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death

Sébastien Cagnol, Ellen Van Obberghen‐Schilling, Jean‐Claude Chambard

APOPTOSIS

Signal TransductionSignaling PathwayCell RegulationApoptosisImmunology +5

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

Sébastien Cagnol, Nathalie Rivard

Oncogene

Systems BiologySignal TransductionOncogenic KrasSignaling PathwayDual-specificity Phosphatase 4 +10

Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms

Benoît Marchand, Isabelle Tremblay, Sébastien Cagnol, +1

Carcinogenesis

Cell DeathPancreatic Cancer CellsSignaling PathwayPancreatic CancerReceptor Tyrosine Kinase +14

Regulation of cell‐matrix adhesion dynamics and Rac‐1 by integrin linked kinase

Etienne Boulter, Dominique Grall, Sébastien Cagnol, +5

The FASEB Journal

Integrin-linked KinaseCell AdhesionImmunologyMolecular BiologyCellular Physiology +16

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

Geneviève Coulombe, Caroline Leblanc, Sébastien Cagnol, +6

Molecular and Cellular Biology

Chronic Inflammatory DiseasesInflammatory Lung DiseaseIntestinal InflammationImmunologyGastroenterology +20