Yugandhar Beesetty

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason Castellanos, Chanjuan Shi et al. · Gastroenterology · 2015 · 188 citations · Full text

Tumor Biology, Pancreatic Cancer, Medicine +10

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Nagaraj S. Nagathihalli, Yugandhar Beesetty, Wooin Lee et al. · Cancer Research · 2014 · 108 citations · Full text

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 52 citations · Full text

Combinatorial Chemistry, Gtp-bound Ras, Molecular Biology +27

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Jason R. Abbott, Timothy R. Hodges, R. Nathan Daniels et al. · Journal of Medicinal Chemistry · 2018 · 41 citations · Full text

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Dhruba Sarkar, Edward T. Olejniczak, Jason Phan et al. · Journal of Medicinal Chemistry · 2020 · 26 citations · Full text