Caroline J. Breitbach

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Jeong Heo, Tony Reid, Leyo Ruo et al. · Nature Medicine · 2013 · 753 citations · Full text

Vaccination, Dose-finding Clinical Trial, Hepatology +12

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

Caroline J. Breitbach, James M. Burke, Derek J. Jonker et al. · Nature · 2011 · 539 citations

Molecular Virology, Viral Pathogenesis, Immunology +6

Translational control of the innate immune response through IRF-7

Rodney Colina, Mauro Costa‐Mattioli, Ryan J.O. Dowling et al. · Nature · 2008 · 311 citations

Inflammation, Host Response, Innate Immune System +8

The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

Kelley A. Parato, Caroline J. Breitbach, Fabrice Le Bœuf et al. · Molecular Therapy · 2011 · 300 citations · Full text

Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow

Caroline J. Breitbach, Jennifer M Paterson, Chantal G. Lemay et al. · Molecular Therapy · 2007 · 274 citations · Full text