Marc Ceusters

¹⁸F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

Michel Koole, Mark E. Schmidt, Anja Hijzen et al. · Journal of Nuclear Medicine · 2018 · 91 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432

Brian Lord, Leah Aluisio, James R. Shoblock et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 73 citations

Medicine, Neuroscience, Pharmacology +16

P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy

Halima Amhaoul, Idrish Ali, Marco Mola et al. · Neuropharmacology · 2016 · 68 citations

Medicine, Neuroscience, Pharmacology +7

4-Methyl-6,7-dihydro-4<i>H</i>-triazolo[4,5-<i>c</i>]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Michael A. Letavic, Brad M. Savall, Brett D. Allison et al. · Journal of Medicinal Chemistry · 2017 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants

Maarten Timmers, Paulien Ravenstijn, Liwen Xi et al. · Journal of Psychopharmacology · 2018 · 63 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +12