Concepedia

Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432

Brian Lord, Leah Aluisio, James R. Shoblock, Robert A. Neff, Elena I. Varlinskaya, Marc Ceusters, Timothy W. Lovenberg, Nicholas I. Carruthers, Pascal Bonaventure, Michael A. Letavic,

Journal of Pharmacology and Experimental Therapeutics · 2014 · 73 citations · 29 references

DOI

Concepts

References

29

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Sun Ho Kim, Jin Mo Chung · Pain · 1992 · 3K citations

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Altered Cytokine Production in Mice Lacking P2X7Receptors

Mike Solle, Jeff M. Labasi, David G. Perregaux et al. · Journal of Biological Chemistry · 2001 · 925 citations · Full text

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Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Iain P. Chessell, Jonathan P. Hatcher, C. Bountra et al. · Pain · 2005 · 784 citations

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Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Edward Keystone, Millie M Wang, Mark Layton et al. · Annals of the Rheumatic Diseases · 2012 · 310 citations

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Efficacy and Safety of CE-224,535, an Antagonist of P2X<sub>7</sub>Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

Thomas Stock, Bradley J. Bloom, Nathan Wei et al. · The Journal of Rheumatology · 2012 · 238 citations · Full text

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