Thomas A. Brandt

Strain-release amination

Ryan Gianatassio, Justin M. Lopchuk, Jie Wang et al. · Science · 2016 · 546 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +11

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

Steven M. Mennen, Carolina Alhambra, C. Liana Allen et al. · Organic Process Research & Development · 2019 · 535 citations

Pharmaceutical Research, Pharmaceutical Innovation, Hit Identification +25

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

Justin M. Lopchuk, Kasper Fjelbye, Yu Kawamata et al. · Journal of the American Chemical Society · 2017 · 326 citations · Full text

Discovery of a Clinical Candidate from the Structurally Unique Dioxa-bicyclo[3.2.1]octane Class of Sodium-Dependent Glucose Cotransporter 2 Inhibitors

Vincent Mascitti, Tristan S. Maurer, Ralph P. Robinson et al. · Journal of Medicinal Chemistry · 2011 · 133 citations · Full text

Pharmaceutical Science, Clinical Candidate, Pharmacotherapy +16

Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714

David H. Brown Ripin, Dennis E. Bourassa, Thomas A. Brandt et al. · Organic Process Research & Development · 2005 · 75 citations

Surgical Oncology, Engineering, Kilogram-scale Sonagashira +18