AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Hijai R. Shin, Hyun-Kyung Kim, Sungryong Oh, +6

Nature

Cell AutophagyTranscriptional RegulationSignal TransductionSignaling PathwayAutophagy +3

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin, +6

Nature Cell Biology

Proteinlipid InteractionSignal TransductionNatural SciencesDrive Aberrant GrowthNiemann–pick Type C +6

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, +6

Developmental Cell

Organelle HomeostasisSignal TransductionOxysterolBiochemistryOrganelle Dynamic +8

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

Clive Yik‐Sham Chung, Hijai R. Shin, Charles A. Berdan, +5

Nature Chemical Biology

Vacuolar H+-atpase ActivatesMitophagyCell AutophagySignal TransductionBiochemistry +11

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Jason S. Lee, Yun-Ho Kim, Ik Soo Kim, +15

Molecular Cell

Redox RegulatorPhysiologyHypoxia (Medicine)Induced Reptin MethylationEpigenetics +5

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

Hijai R. Shin, Y. Rose Citron, Lei Wang, +17

Science

Proteinlipid InteractionMolecular PhysiologySignal TransductionBiochemistryOxysterol +12

Hypoxia-induced methylation of a pontin chromatin remodeling factor

Jason S. Lee, Yun-Ho Kim, Jinhyuk Bhin, +8

Proceedings of the National Academy of Sciences

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Dongha Kim, Hye Jin Nam, Wonhwa Lee, +9

Molecular Cell

InflammationSignal TransductionSignaling PathwayMedicineImmune Regulation +10

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Suprit Gupta, Julian Yano, Vincent Mercier, +11

Nature Cell Biology

Pancreatic CancerCell RegulationMedicineAutophagyPancreatic Cancer Growth +8

Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

Young Suk Yu, Hijai R. Shin, Dongha Kim, +9

Nature Communications