Charles A. Berdan

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin et al. · Nature Cell Biology · 2019 · 301 citations

Proteinlipid Interaction, Signal Transduction, Natural Sciences +8

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

Clive Yik‐Sham Chung, Hijai R. Shin, Charles A. Berdan et al. · Nature Chemical Biology · 2019 · 179 citations

Vacuolar H+-atpase Activates, Mitophagy, Cell Autophagy +13

A Cellular Mechanism to Detect and Alleviate Reductive Stress

Andrew G. Manford, Fernando Rodríguez-Pérez, Karen Y. Shih et al. · Cell · 2020 · 171 citations · Full text

Cell Physiology, Reductive Stress, Signal Transduction +10

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

Charles A. Berdan, Raymond Ho, Haley S. Lehtola et al. · Cell chemical biology · 2019 · 88 citations · Full text

Cell Adhesion, Breast Cancer Cells, Cell-matrix Interaction +9

Ablation of PM20D1 reveals <i>N</i> -acyl amino acid control of metabolism and nociception

Jonathan Z. Long, Alexander M. Roche, Charles A. Berdan et al. · Proceedings of the National Academy of Sciences · 2018 · 58 citations · Full text