Landscape of Acquired Resistance to Osimertinib in <i>EGFR</i> -Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired <i>RET</i> Fusion

Zofia Piotrowska, Hideko Isozaki, Jochen K. Lennerz, +23

Cancer Discovery

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

Hideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, +37

Nature

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +2

Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases

Hideko Isozaki, Eiki Ichihara, Nagio Takigawa, +13

Cancer Research

OncologyMedicineReceptor Tyrosine KinaseAlectinib ResistancePharmacology +13

Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer.

L. Chen, N. Matsubara, Teruo Yoshino, +7

PubMed

Tumor BiologySquamous Cell CancerEsophageal CancerMedicineCancer Cell Biology +12

MUC1-C Is a Common Driver of Acquired Osimertinib Resistance in NSCLC

Naoki Haratake, Hiroki Ozawa, Yoshihiro Morimoto, +16

Journal of Thoracic Oncology

Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines.

Hiromichi Yamane, Hideko Isozaki, Masami Takeyama, +7

Europe PMC (PubMed Central)

Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation

Nagio Takigawa, Nobuaki Ochi, Hiromichi Yamane, +8

Drug Design Development and Therapy

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

Hideko Isozaki, Ammal Abbasi, Naveed Nikpour, +33

Sequential Targeted TherapiesCancer BiologyTumor BiologyDrug ResistanceOncology +15

Downregulation of <i><scp>TBXAS</scp>1</i> in an iron‐induced malignant mesothelioma model

Daisuke Minami, Nagio Takigawa, Yuka Kato, +15

Cancer Science

Tumor BiologyTumoral PathologyMalignant DiseaseOncogenic AgentMalignant Mesothelioma +9

A New Human Lung Adenocarcinoma Cell Line Harboring the EML4-ALK Fusion Gene

Hideko Isozaki, Masayuki Yasugi, Nagio Takigawa, +8

Japanese Journal of Clinical Oncology