The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers

Jack Shi, Xuejun Chen, Fiona Lee, +6

The Journal of Clinical Pharmacology

ImmunologyPharmacotherapyInflammatory ArthritisTranslational PharmacologyPre-clinical Pharmacology +16

Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis

Naresh Punwani, Peggy Scherle, Robert Flores, +6

Journal of the American Academy of Dermatology

MedicinePharmacologyClinical DermatologyPreliminary Clinical ActivityTopical Jak1/2 Inhibitor +3

The Pharmacokinetics, Pharmacodynamics, and Safety of Orally Dosed INCB018424 Phosphate in Healthy Volunteers

Jack Shi, Xuejun Chen, Ryan McGee, +7

The Journal of Clinical Pharmacology

Jak EnzymesIncb018424 PhosphateMedicineHealthy VolunteersToxicology +6

The Effect of CYP3A4 Inhibition or Induction on the Pharmacokinetics and Pharmacodynamics of Orally Administered Ruxolitinib (INCB018424 Phosphate) in Healthy Volunteers

Jack Shi, Xuejun Chen, Thomas Emm, +8

The Journal of Clinical Pharmacology

Incb018424 PhosphateChemoprevention StrategyImmunologyWhole BloodPharmacotherapy +16

Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans

Adam D. Shilling, Frank M. Nedza, Thomas Emm, +11

Drug Metabolism and Disposition

Downmodulation of key inflammatory cell markers with a topical Janus kinase 1/2 inhibitor

Naresh Punwani, Timothy C. Burn, Peggy Scherle, +14

British Journal of Dermatology

Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients

Xuejun Chen, Jack Shi, Thomas Emm, +7

Clinical Pharmacology in Drug Development

Incb018424 PhosphateHealthy SubjectsRenal PathologyPharmacotherapyPhysiologically-based Pharmacokinetic Modeling +20

Impact on Creatinine Renal Clearance by the Interplay of Multiple Renal Transporters: A Case Study with INCB039110

Yan Zhang, Mark S. Warren, Xuexiang Zhang, +6

Drug Metabolism and Disposition

Evaluation of the pharmacokinetics of pemigatinib in patients with impaired hepatic or renal function

Tao Ji, Kevin Rockich, Noam Epstein, +5

British Journal of Clinical Pharmacology

Effect of Itraconazole or Rifampin on Itacitinib Pharmacokinetics When Administered Orally in Healthy Subjects

April Barbour, Naresh Punwani, Noam Epstein, +7

The Journal of Clinical Pharmacology

Healthy SubjectsImmunologyPharmacotherapyImmunotherapyPharmacodynamic Modeling +19