The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers

Jack Shi, Xuejun Chen, Fiona Lee, +6

The Journal of Clinical Pharmacology

ImmunologyPharmacotherapyInflammatory ArthritisTranslational PharmacologyPre-clinical Pharmacology +16

The Pharmacokinetics, Pharmacodynamics, and Safety of Orally Dosed INCB018424 Phosphate in Healthy Volunteers

Jack Shi, Xuejun Chen, Ryan McGee, +7

The Journal of Clinical Pharmacology

Jak EnzymesIncb018424 PhosphateMedicineHealthy VolunteersToxicology +6

The Effect of CYP3A4 Inhibition or Induction on the Pharmacokinetics and Pharmacodynamics of Orally Administered Ruxolitinib (INCB018424 Phosphate) in Healthy Volunteers

Jack Shi, Xuejun Chen, Thomas Emm, +8

The Journal of Clinical Pharmacology

Incb018424 PhosphateChemoprevention StrategyImmunologyWhole BloodPharmacotherapy +16

Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans

Adam D. Shilling, Frank M. Nedza, Thomas Emm, +11

Drug Metabolism and Disposition

Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic ( <i>S</i> )-Isothiazolidinone Phosphotyrosine Mimetic

Andrew P. Combs, Wenyu Zhu, Matthew L. Crawley, +24

Journal of Medicinal Chemistry

Pharmacokinetics of intravenously administered ciprofloxacin in patients with various degrees of renal function

George L. Drusano, Matthew R. Weir, Alan Forrest, +3

Antimicrobial Agents and Chemotherapy

Various DegreesRenal FunctionMedicineKidney FailureChronic Kidney Disease +9

High-performance liquid chromatographic assay for the determination of 2′-deoxy-3′-thiacytidine (lamivudine) in human plasma

Joanna J Zheng, Steven T. Wu, Thomas Emm

Journal of Chromatography B Biomedical Sciences and Applications

Medicinal ChemistryBiochemistryMedicineNatural SciencesBioanalysis +10

Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients

Xuejun Chen, Jack Shi, Thomas Emm, +7

Clinical Pharmacology in Drug Development

Incb018424 PhosphateHealthy SubjectsRenal PathologyPharmacotherapyPhysiologically-based Pharmacokinetic Modeling +20

Determination of naltrexone and its major metabolite, 6-β-naltrexol, in human plasma using liquid chromatography with electrochemical detection

Anna F. Davidson, Thomas Emm, Henry J. Pieniaszek

Journal of Pharmaceutical and Biomedical Analysis

Pharmacological StudyElectrochemical DetectionMedicineBioanalysisHuman Plasma +7

Clinical Benefit of INCB7839, a Potent and Selective Inhibitor of ADAM10 and ADAM17, in Combination with Trastuzumab in Metastatic HER2 Positive Breast Cancer Patients.

Steven Friedman, Richard Levy, William M. Garrett, +19

Cancer Research

Breast OncologyImmunologyPharmacotherapyTumor BiologyHer2 Cleavage +14