n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE 2 induced ERK-1 and -2 and HIF-1α induction pathway

Gabriella Calviello, Fiorella Di Nicuolo, Simona Gragnoli, +7

Carcinogenesis

Chemoprevention StrategyPathologyCox-2 ExpressionCancer BiologyMammary Gland Development +21

DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: Involvement of the oxidative mechanism

Gabriella Calviello, Elisabetta Piccioni, Alma Boninsegna, +5

Toxicology and Applied Pharmacology

ChromatinDna DamageBiochemistryApoptosis InductionMedicine +10

Antioxidant Effect of Ferulic Acid in Isolated Membranes and Intact Cells:  Synergistic Interactions with α-Tocopherol, β-Carotene, and Ascorbic Acid

Sonia Trombino, Simona Serini, Fiorella Di Nicuolo, +5

Journal of Agricultural and Food Chemistry

Lipid PeroxidationAntioxidant EfficiencyRedox BiologyAntioxidant MechanismOxidative Stress +14

β-Carotene Regulates NF-κB DNA-Binding Activity by a Redox Mechanism in Human Leukemia and Colon Adenocarcinoma Cells

Paola Palozza, Simona Serini, Angela Torsello, +6

Journal of Nutrition

Redox SignalingTumor BiologyBiochemistryHuman LeukemiaMedicine +8

β-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells

Paola Palozza, Gabriella Calviello, Simona Serini, +4

Free Radical Biology and Medicine

Cancer ResearchCarotenoidBiochemistryOxy-radical ProductionMedicine +9

Omega-3 PUFA Loaded in Resveratrol-Based Solid Lipid Nanoparticles: Physicochemical Properties and Antineoplastic Activities in Human Colorectal Cancer Cells In Vitro

Simona Serini, Roberta Cassano, Paola Antonia Corsetto, +3

International Journal of Molecular Sciences

EngineeringChemoprevention StrategyNutraceutical IngredientNanomedicineFatty Acids +16

Docosahexaenoic acid induces proteasome-dependent degradation of  -catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2

Gabriella Calviello, Federica Resci, Simona Serini, +6

Carcinogenesis

Chemoprevention StrategyMedicineTumor GrowthApoptosisPharmacology +10

Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil

Gabriella Calviello, Fiorella Di Nicuolo, Simona Serini, +5

Cancer Chemotherapy and Pharmacology

Docosahexaenoic AcidOncologyMedicineColorectal CancerPathology +5

DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines

Elena Fasano, Simona Serini, Elisabetta Piccioni, +5

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Tumor BiologySignaling PathwayMolecular PathwayMedicineApoptosis +9

β-Carotene Downregulates the Steady-State and Heregulin-α–Induced COX-2 Pathways in Colon Cancer Cells

Paola Palozza, Simona Serini, Nicola Maggiano, +4

Journal of Nutrition

Tumor BiologyHeregulin-α–induced Cox-2 PathwaysGastrointestinal OncologyMedicineColon Cancer Cells +10