Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, +31

Cell

VaccinationGerminal Center ResponsesHuman RetrovirusImmunologyAntiviral Therapy +6

CXCL13 is a plasma biomarker of germinal center activity

Colin Havenar‐Daughton, Madelene Lindqvist, Antje Heit, +11

Proceedings of the National Academy of Sciences

ImmunologyPlasma BiomarkerPathologyImmunodominanceImmunologic Mechanism +15

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells

Samantha Reiss, Amy E. Baxter, Kimberly M. Cirelli, +9

PLoS ONE

Laboratory ImmunologyT-regulatory CellImmunologyAntigen ProcessingCd4 T Cell Responses +16

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood

Jennifer M. Dan, Cecilia S. Lindestam Arlehamn, Daniela Weiskopf, +7

The Journal of Immunology

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

Colin Havenar‐Daughton, Diane G. Carnathan, Alba Torrents de la Peña, +25

Cell Reports

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Matthias Pauthner, Joseph P. Nkolola, Colin Havenar‐Daughton, +28

Immunity

VaccinationVaccinologyCross-protectionVaccine DevelopmentVaccine Target +9

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

Daniel W. Kulp, Jon M. Steichen, Matthias Pauthner, +18

Nature Communications

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

Colin Havenar‐Daughton, Anita Sarkar, Daniel W. Kulp, +20

Science Translational Medicine

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

Colin Havenar‐Daughton, Samantha Reiss, Diane G. Carnathan, +10

The Journal of Immunology

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

Amit A. Upadhyay, Robert C. Kauffman, Amber Wolabaugh, +12

Genome Medicine