An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

John D. Klement, Amy V. Paschall, Priscilla S. Redd, +7

Journal of Clinical Investigation

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Chunwan Lu, John D. Klement, Mohammed L. Ibrahim, +5

Journal for ImmunoTherapy of Cancer

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

Mohammed L. Ibrahim, John D. Klement, Chunwan Lu, +8

Cell Reports

Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment

John D. Klement, Priscilla S. Redd, Chunwan Lu, +8

Cancer Cell

ImmunologyPathologyImmunotherapyTumor BiologyTumor Immunology +16

Asah2 Represses the p53–Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis

Huabin Zhu, John D. Klement, Chunwan Lu, +13

The Journal of Immunology

WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

Chunwan Lu, Zhuoqi Liu, John D. Klement, +7

Journal for ImmunoTherapy of Cancer

IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells

Wei Xiao, John D. Klement, Chunwan Lu, +2

The Journal of Immunology

Autocrine IL6-Mediated Activation of the STAT3–DNMT Axis Silences the TNFα–RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells

Alyssa D. Smith, Chunwan Lu, Daniela Payne, +11

Cancer Research

SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells

Priscilla S. Redd, Mohammed L. Ibrahim, John D. Klement, +5

Cancer Research

SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion

Chunwan Lu, Dafeng Yang, John D. Klement, +14

Cancer Immunology Research