Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

Shu-Xing Li, Sun Huang, Nina Bren, +4

Nature Neuroscience

Molecular PharmacologySignal TransductionBiochemistryLigand-binding DomainMedicine +8

De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias

Katherine L. Helbig, Robert J. Lauerer, Jacqueline C Bahr, +129

The American Journal of Human Genetics

Epileptic EncephalopathyNeurobiology Of DiseasePathogenesisExperimental NeuropathologyPathology +8

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera

Sun Huang, Shu-Xing Li, Nina Bren, +4

Biochemical Journal

Crystal StructureProteinlipid InteractionImmunologyMolecular BiologyPeptide Science +16

The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels

Vinícius M. Gadotti, Sun Huang, Gerald W. Zamponi

Molecular Brain

Differential regulation of Ca_v3.2 and Ca_v2.2 calcium channels by CB₁ receptors and cannabidiol

Erika K. Harding, Ivana A. Souza, María A. Gandini, +6

British Journal of Pharmacology

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Sun Huang, Lina Chen, Chris Bladen, +2

Molecular Brain

A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Robin N. Stringer, Bohumila Jurkovičová-Tarabová, Sun Huang, +9

Molecular Brain

Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide

Marwa H. El‐Wakil, Mohamed Teleb, Marwa M. Abu‐Serie, +3

Bioorganic Chemistry

Medicinal ChemistryPolymer-drug ConjugateMedicineAnti-cancer AgentStructural Optimization +3

Icariside II, a Prenyl-Flavonol, Alleviates Inflammatory and Neuropathic Pain by Inhibiting T-Type Calcium Channels and USP5-Cav3.2 Interactions

Md Yousof Ali, Vinícius M. Gadotti, Sun Huang, +5

ACS Chemical Neuroscience

Pain MedicineNeuropathic PainMolecular PainPharmacotherapyExperimental Pharmacology +17

Effect of ABT-639 on Cav3.2 channel activity and its analgesic actions in mouse models of inflammatory and neuropathic pain

Flavia Tasmin Techera Antunes, Sun Huang, Lina Chen, +1

European Journal of Pharmacology

InflammationHealth SciencesAcute PainPain MedicineMedicine +10