The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

Damon J. Tumes, Atsushi Onodera, Akane Suzuki, +9

Immunity

ChromatinLineage PlasticityDevelopmental BiologyCell RegulationLymphocyte Development +6

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

Yusuke Endo, Hikari K. Asou, Nao Matsugae, +6

Cell Reports

Neuronal enhancers are hotspots for DNA single-strand break repair

Wei Wu, Sarah E. Hill, William J. Nathan, +22

Nature

Neuronal EnhancersChromatinGenome InstabilityDna DamageMolecular Neuroscience +5

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

Yusuke Endo, Kiyoshi Hirahara, Tomohisa Iinuma, +12

Immunity

AsthmaInflammationCytokineInflammatory Lung DiseaseCell Pathogenicity +8

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

Makoto Kuwahara, Masakatsu Yamashita, Kenta Shinoda, +9

Nature Immunology

CytokineTranscriptional RegulationTh2 DifferentiationSignal TransductionTranscription Factor Sox4 +7

Type II membrane protein CD69 regulates the formation of resting T-helper memory

Kenta Shinoda, Koji Tokoyoda, Asami Hanazawa, +8

Proceedings of the National Academy of Sciences

Adaptive Immune SystemImmunologyAntigen ProcessingCd4 T Cell ResponsesImmunotherapy +17

Thy1⁺IL-7⁺lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

Kenta Shinoda, Kiyoshi Hirahara, Tomohisa Iinuma, +9

Proceedings of the National Academy of Sciences

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Makoto Kuwahara, Wataru Ise, Mizuki Ochi, +14

Nature Communications

Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells

Chiaki Iwamura, Kenta Shinoda, Mineka Yoshimura, +3

Allergology International

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

Takako Miki-Hosokawa, Akihiro Hasegawa, Chiaki Iwamura, +9

The Journal of Immunology

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyImmune Regulation +16