A-803467, a potent and selective Na _v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

Michael F. Jarvis, Prisca Honoré, Char‐Chang Shieh, +34

Proceedings of the National Academy of Sciences

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Ken McCormack, Sonia Santos, Mark L. Chapman, +15

Proceedings of the National Academy of Sciences

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Na_v1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

Michael E. Kort, Irene Drizin, Robert J. Gregg, +27

Journal of Medicinal Chemistry

Pain DisordersPain MedicineNeuropathic PainMolecular PainPharmacotherapy +18

Synthesis of (−)-11-<i>O</i>-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation

Masaki Ohtawa, Michael J. Krambis, Rok Cerne, +3

Journal of the American Chemical Society

Bioorganic ChemistryTrace PlantEngineeringNeurotransmitterSecondary Metabolite +18

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA_A) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Michael M. Poe, Kashi Reddy Methuku, Guanguan Li, +14

Journal of Medicinal Chemistry

PsychopharmacologyPharmacotherapyPharmaceutical ChemistryMolecular PharmacologyPharmacological Study +15

Structural Locus of the pH Gate in the Kir1.1 Inward Rectifier Channel

Henry Sackin, Mikheil Nanazashvili, Lawrence G. Palmer, +2

Biophysical Journal

Ph GateHyperpolarization (Biology)Molecular BiologyIon ChannelsMembrane Biology +3

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy

Jeffrey M. Witkin, Jodi L. Smith, Xingjie Ping, +19

Neuropharmacology

Selective PotentiatorsFunctional SelectivityMedicineBioavailability EnhancesMechanism Of Action +7

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

Marc J. C. Scanio, Lei Shi, Irene Drizin, +7

Bioorganic & Medicinal Chemistry

Nav1.8 Sodium ChannelPyrazine-based BlockersPain MedicinePharmacologyNeuropathic Pain +9

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Jeffrey M. Witkin, Rok Cerne, Paula G. Davis, +22

Pharmacology Biochemistry and Behavior

Pain MedicineSynaptic TransmissionNeuromodulation TherapiesAnesthetic MechanismMolecular Pain +15

Permeant Cations and Blockers Modulate pH Gating of ROMK Channels

Henry Sackin, A. Vasilyev, Lawrence G. Palmer, +1

Biophysical Journal

BiochemistryRomk ChannelsMembrane TransportIon ChannelsElectrophysiology +3