Kashi Reddy Methuku

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA_A) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Michael M. Poe, Kashi Reddy Methuku, Guanguan Li et al. · Journal of Medicinal Chemistry · 2016 · 47 citations · Full text

Psychopharmacology, Pharmacotherapy, Pharmaceutical Chemistry +17

First <i>In Vivo</i> Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development

Oliver Jonas, David Calligaris, Kashi Reddy Methuku et al. · Journal of Biomedical Nanotechnology · 2016 · 42 citations · Full text

Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABA_A Receptor Positive Allosteric Modulator

Lakeisha Lewter, Janet L. Fisher, Justin N. Siemian et al. · ACS Chemical Neuroscience · 2017 · 41 citations · Full text

Pain Disorders, Pain Medicine, Spinal Gabaa Receptors +19

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy

Jeffrey M. Witkin, Jodi L. Smith, Xingjie Ping et al. · Neuropharmacology · 2018 · 35 citations

Selective Potentiators, Functional Selectivity, Medicine +9

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Jeffrey M. Witkin, Rok Cerne, Paula G. Davis et al. · Pharmacology Biochemistry and Behavior · 2019 · 33 citations · Full text

Pain Medicine, Synaptic Transmission, Neuromodulation Therapies +17