Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Timothy R. Wilson, Jane Fridlyand, Yibing Yan, +15

Nature

MedicineKinase InhibitorsAnti-cancer AgentPharmacologyCancer Growth +4

A role for alpha-synuclein in the regulation of dopamine biosynthesis.

Ruth G. Perez, Jack C. Waymire, Eva Lin, +3

PubMed

NeurotransmitterSocial SciencesDopamine SynthesisDegenerative PathologyProtein Misfolding +14

A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

Ruth G. Perez, Jack C. Waymire, Eva Lin, +3

Journal of Neuroscience

Synaptic SignalingDopamine SynthesisDegenerative PathologyProtein MisfoldingParkinson9s Disease +17

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé, +41

Nature

Molecular DockingUbiquitin BindingDrug TargetMedicineNatural Sciences +5

Exon Array Profiling Detects <i>EML4-ALK</i> Fusion in Breast, Colorectal, and Non–Small Cell Lung Cancers

Eva Lin, Li Li, Yinghui Guan, +6

Molecular Cancer Research

PathologyEml4-alk FusionCancer BiologyTumor BiologyCancer Detection +16

Reproducible pharmacogenomic profiling of cancer cell line panels

Peter M. Haverty, Eva Lin, Jenille Tan, +8

Nature

Tumor HeterogeneityCancer GenomicsReproducible Pharmacogenomic ProfilingMedicineCell Biology +2

Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

Stanton Kok, Roberto Gambari, Chung Chui, +5

Bioorganic & Medicinal Chemistry

MedicineAnti-cancer ActivityOrganic ChemistryAnti-cancer AgentHeterocycle Chemistry +3

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Thijs J. Hagenbeek, Marc Hafner, Rana Mroue, +38

Nature Cancer

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Catherine Wilson, Xiaofen Ye, Thinh Pham, +9

Cancer Research

Antimitotic DrugsMedicinePharmacologyKinase InhibitorsEmt Setting +10

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Catherine Wilson, Katrina Nicholes, Daisy Bustos, +5

Oncotarget

Cancer MetastasisSrc/fak Pathway InhibitionCancer BiologyTumor BiologyDrug Resistance +14