Timothy R. Hercus

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

Guido Hansen, Timothy R. Hercus, Barbara J. McClure et al. · Cell · 2008 · 302 citations · Full text

Inflammation, Cytokine Receptor Activation, Gm-csf Receptor Complex +13

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

Joanna M. Woodcock, B. Zacharakis, Geert Plaetinck et al. · The EMBO Journal · 1994 · 115 citations · Full text

Inflammation, Cytokine, Signal Transduction +12

Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

Angel F. López, M Shannon, Timothy R. Hercus et al. · The EMBO Journal · 1992 · 112 citations · Full text

Biological Activity, Inflammation, Low Affinity Binding +11

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

Timothy R. Hercus, C.J. Bagley, Bronwyn Cambareri et al. · Proceedings of the National Academy of Sciences · 1994 · 106 citations · Full text

Immunology, Escherichia Coli, Immunologic Mechanism +16

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common β-subunit

Michelle Perugini, Anna Brown, Diana Salerno et al. · Blood · 2010 · 67 citations · Full text