Joanna F. McGouran

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

Inflammation, Reductive Stress, Anti-inflammatory +10

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

Neil P. Blackledge, Anca M. Farcas, Takashi Kondo et al. · Cell · 2014 · 742 citations · Full text

Molecular Biology, Epigenetics, Transcriptional Regulation +18

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

Anca M. Farcas, Neil P. Blackledge, Ian Sudbery et al. · eLife · 2012 · 470 citations · Full text

Biology, Chromatin, Developmental Biology +15

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

A.P. Turnbull, Stephanos Ioannidis, Wojciech Krajewski et al. · Nature · 2017 · 448 citations

Drug Target, Usp7 Inhibition, Medicine +4

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

Mikael Altun, Holger Kramer, Lianne I. Willems et al. · Chemistry & Biology · 2011 · 389 citations

Proteomic Technology, Biochemistry, Natural Sciences +4