Diane Wong

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

Medicine, Pharmacokinetics, Pharmacology +16

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Brian L. Lin, Damian Matera, Julia F. Doerner et al. · Proceedings of the National Academy of Sciences · 2019 · 149 citations · Full text

Medicine, Cardiology, Pharmacology +17

Discovery of Two Clinical Histamine H ₃ Receptor Antagonists: <i>trans</i> - <i>N</i> -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and <i>trans</i> -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- <i>N</i> -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Travis T. Wager, Betty Pettersen, Anne W. Schmidt et al. · Journal of Medicinal Chemistry · 2011 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of 4-(5-Methyloxazolo[4,5-<i>b</i>]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

Christopher J. O’Donnell, Bruce N. Rogers, Brian S. Bronk et al. · Journal of Medicinal Chemistry · 2009 · 74 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat

Carine M. Boustany‐Kari, Paul C. Harrison, Hu Sheng Qian et al. · Journal of Pharmacology and Experimental Therapeutics · 2016 · 56 citations · Full text

Medicine, Nephrology, Pharmacology +16