Genome-wide cell-free DNA fragmentation in patients with cancer

Stephen Cristiano, Alessandro Leal, Jillian Phallen, +33

Nature

Direct detection of early-stage cancers using circulating tumor DNA

Jillian Phallen, Mark Sausen, Vilmos Adleff, +34

Science Translational Medicine

EngineeringDirect DetectionPathologyNucleic Acid BiomarkersCancer Detection +14

Assessment of Resistance Mechanisms and Clinical Implications in Patients With<i>EGFR</i>T790M–Positive Lung Cancer and Acquired Resistance to Osimertinib

Geoffrey R. Oxnard, Yuebi Hu, Kathryn F. Mileham, +12

JAMA Oncology

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Collin M. Blakely, Thomas B.K. Watkins, Wei Wu, +26

Nature Genetics

Co-occurring Genetic AlterationsOncologySomatic VariantMedicineGenetics +8

<i>EGFR</i> -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes

Nicolas Marcoux, Scott Gettinger, Grainne M. O’Kane, +18

Journal of Clinical Oncology

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

Laetitia Seguin, Shumei Kato, Aleksandra Franovic, +17

Nature Cell Biology

Tumor BiologyIntegrin β3–Kras–ralbEgfr InhibitionMedicineStem Cells +11

Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma

Maria Schwaederlé, Sandip Pravin Patel, Hatim Husain, +6

Clinical Cancer Research

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay

Maria Schwaederlé, Hatim Husain, Paul T. Fanta, +8

Oncotarget

Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients

Maria Schwaederlé, Hatim Husain, Paul T. Fanta, +8

Clinical Cancer Research

Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer

Georg Lurje, W. Zhang, Anne M. Schultheis, +8

Annals of Oncology

MedicineTumor RecurrenceImmunologyColorectal CancerPathology +6