Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

Mark R. Schmitt, Matthias Schewe, Andrea Sacchetti, +10

Cell Reports

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer

Matthias Schewe, Patrick Franken, Andrea Sacchetti, +12

Cell stem cell

InflammationSignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunology +7

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden

Marten van der Zee, Andrea Sacchetti, Medine Cansoy, +7

Cancer Research

GynecologyCancer Stem-like CellsTumor BiologySignaling PathwayStem Cells +16

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, +15

eLife

Identification of Quiescent, Stem-Like Cells in the Distal Female Reproductive Tract

Yongyi Wang, Andrea Sacchetti, Matthijs R. van Dijk, +7

PLoS ONE

GynecologyFemale Reproductive FunctionMenstrual CycleReproductive BiologyEpigenetics +22

Cancer stemness in Wnt-driven mammary tumorigenesis

Joana Monteiro, Cláudia Gaspar, Wilfrid Richer, +7

Carcinogenesis

Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation

Mathijs Verhagen, Rosalie Joosten, Mark R. Schmitt, +14

Nature Genetics

Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

Tong Xu, Mathijs Verhagen, Rosalie Joosten, +5

eLife

Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer

Tong Xu, Mathijs Verhagen, Miriam Teeuwssen, +13

Cell Death and Differentiation

Ectopic activation of WNT signaling in human embryonal carcinoma cells and its effects in short- and long-term in vitro culture

Yaser Atlasi, Rebecca T. van Dorsten, Andrea Sacchetti, +4

Scientific Reports