Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

Suzanne Lesage, Valérie Drouet, Elisa Majounie, +212

The American Journal of Human Genetics

Cell AutophagyMitophagyMitochondrial FunctionGeneticsAutophagy +5

Loss of C9 <scp>ORF</scp> 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

Chantal Sellier, Maria‐Letizia Campanari, Camille Corbier, +8

The EMBO Journal

Cell AutophagyMitophagyNeurodegenerative DiseasesMolecular NeurosciencePolyq Ataxin‐2 +10

Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis

Sorana Ciura, Serena Lattante, Isabelle Le Ber, +4

Annals of Neurology

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis

Dina Aggad, J. Ricardo Martinez, Elsa Tremblay, +16

JCI Insight

Simple Genetic ModelsAmyotrophic Lateral SclerosisNeuroengineeringNeurophysiologyMedicine +13

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio

Alexandra Vaccaro, Shunmoogum A. Patten, Sorana Ciura, +5

PLoS ONE

D. RerioMolecular BiologySocial SciencesToxicological MechanismOxidative Stress +18

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD

Serena Lattante, Hortense de Calbiac, Isabelle Le Ber, +3

Human Molecular Genetics

Depdc5 knockdown causes <scp>mTOR</scp>‐dependent motor hyperactivity in zebrafish

Hortense de Calbiac, Adriana Dabacan, Elise Marsan, +8

Annals of Clinical and Translational Neurology

The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway

Sorana Ciura, Chantal Sellier, Maria‐Letizia Campanari, +2

Autophagy

GeneticsCell DeathMolecular BiologyRepeat ExpansionsSocial Sciences +15

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

Serena Lattante, Isabelle Le Ber, Agnès Camuzat, +7

Neurobiology of Aging

Neurodegenerative DiseasesAlzheimer's DiseaseDementiaPathologyDegenerative Disease +10

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish

Maria‐Letizia Campanari, Anca Marian, Sorana Ciura, +1

Cells