The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

Toyohide Shinkawa, Kazuyasu Nakamura, Naoko Yamane, +9

Journal of Biological Chemistry

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

Hiroshi Yano, S. Nakanishi, Koutarou D. Kimura, +5

Journal of Biological Chemistry

ImmunologyCellular PharmacologyExperimental PharmacologyCellular PhysiologyRbl-2h3 Cells +17

Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

Keisuke Sasaki, Keigo Kurata, Kikuko Funayama, +5

Journal of Biological Chemistry

Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma

Rinpei Niwa, Emi Shoji-Hosaka, Mikiko Sakurada, +7

Cancer Research

Km2760 FunctionsIgg1 Antibody Km2760Cancer ImmunosurveillanceMedicineImmunology +11

A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils

Akeo Shinkai, Hajime Yoshisue, Masamichi Koike, +10

The Journal of Immunology

Dramatically Different Phenotypes in Mouse Models of Human Tay-Sachs and Sandhoff Diseases

Daniel J. Phaneuf, Nobuaki Wakamatsu, Jingqi Huang, +13

Human Molecular Genetics

Activated platelets induce superoxide anion release by monocytes and neutrophils through P-selectin (CD62).

Kosei Nagata, Tsutomu Tsuji, Naoko Todoroki, +5

The Journal of Immunology

Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection.

Keisuke Sasaki, Etsuji Watanabe, Kenji Kawashima, +6

Journal of Biological Chemistry

Bioorganic ChemistryGlycobiologyImmunologyMolecular BiologyExpression Cloning +19

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

Nobuo Hanai, Taeko Dohi, Gustavo A. Nores, +1

Journal of Biological Chemistry

ImmunologyCell GrowthGliomaTumor BiologySignaling Pathway +17

Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases

Jingqi Huang, Jacquetta M. Trasler, Suleiman A. Igdoura, +3

Human Molecular Genetics