Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Albena T. Dinkova‐Kostova, Karen T. Liby, Katherine K. Stephenson, +9

Proceedings of the National Academy of Sciences

Lipid PeroxidationCell DeathPotent Triterpenoid InducersRedox BiologyOxidative Stress +15

The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling

Karen T. Liby, Thomas Hock, Mark M. Yore, +11

Cancer Research

A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.

Nanjoo Suh, Yongping Wang, Charlotte R. Williams, +4

PubMed

Breast OncologyChemoprevention StrategyPathologyClassic Rat ModelCancer Biology +14

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Arie Neymotin, Noel Y. Calingasan, Elizabeth Wille, +8

Free Radical Biology and Medicine

Amyotrophic Lateral SclerosisMolecular NeuroscienceMedicineNeuroprotectionNeurology +7

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

Lichuan Yang, Noel Y. Calingasan, Bobby Thomas, +11

PLoS ONE

Lipid PeroxidationCell DeathRedox BiologyOxidative StressNeuroinflammation +16

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

Andrew E. Place, Nanjoo Suh, Charlotte R. Williams, +9

PubMed

ImmunologyLeukemia CellsU937 Leukemia CellsCancer BiologyHuman Leukemia +16

The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice

Karen T. Liby, Darlene B. Royce, Charlotte R. Williams, +7

Cancer Research

The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

Karen T. Liby, Nga Voong, Charlotte R. Williams, +6

Clinical Cancer Research

Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.

Nanjoo Suh, Anita B. Roberts, Stephanie Birkey Reffey, +10

PubMed

Synthetic TriterpenoidsTgf-beta SuperfamilySignal TransductionAngiogenesisBone Morphogenic Protein +11

Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer

Karen T. Liby, Darlene B. Royce, Renee Risingsong, +4

Cancer Prevention Research

OncologyPancreatic CancerKpc Transgenic MiceOncogenic AgentMedicine +10