Concepedia

Melanie S. Brennan

MS

6

Publications

3.3K

Citations

6

H-Index

2015

Active since

Affiliations

Biogen (United States)(Current)

Boston University

Melanie S. Brennan is an author at Biogen (United States) specializing in medicine, neurodegenerative diseases, and alzheimer's disease.

Top concepts

Publications per year

2015–2021

6

Publications

6

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Jeff Sevigny, Ping Chiao, Thierry Bussière et al. · Nature · 2016 · 3K citations

, , +7

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

Melanie S. Brennan, Maria F. Matos, Bing Li et al. · PLoS ONE · 2015 · 169 citations · Full text

, , +19

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

Melanie S. Brennan, Maria F. Matos, K. Richter et al. · Scientific Reports · 2017 · 86 citations · Full text

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Melanie S. Brennan, Hiral Patel, Norm Allaire et al. · Antioxidants and Redox Signaling · 2016 · 57 citations

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Robert H. Scannevin, Sowmya Chollate, Melanie S. Brennan et al. · Neuropharmacology · 2015 · 14 citations

, , +9

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