Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Robert H. Scannevin, Sowmya Chollate, Mi-Young Jung, +8

Journal of Pharmacology and Experimental Therapeutics

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

Jing Wu, Ronald S. Petralia, Hideaki Kurushima, +14

Cell

Cell DeathProtein MisfoldingIntracellular TraffickingCellular BiochemistrySystems Biology +4

Activin, Inhibin, and Follistatin in Zebrafish Ovary: Expression and Role in Oocyte Maturation1

Tingting Wu, Hiral Patel, Spencer T. Mukai, +5

Biology of Reproduction

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Diane C. Cabelof, Hiral Patel, Qing Chen, +4

Blood

Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice

Archana Unnikrishnan, Julian J. Raffoul, Hiral Patel, +6

Free Radical Biology and Medicine

Reductive StressDevelopmental BiologyExcision Repair PathwayOxidative Stress AltersRedox Regulator +8

High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction

Julie H. Rennison, Tracy A McElfresh, Isidore C Okere, +10

American Journal of Physiology-Heart and Circulatory Physiology

Heart FailureHigh-fat Diet PostinfarctionLipid PeroxidationOxidative StressCardiovascular Translational Research +18

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow

A. Middleton, Joe Reynolds, S. Cable, +17

Toxicological Sciences

Animal ProtectionSafety ScienceSystemic Cmax LevelsSafety PolicyInjury Prevention +21

Decreased cytochrome <i>c</i> mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria

John F. O’Toole, Hiral Patel, Colin Naples, +2

Biochemical Journal

Mitochondrial BiologyRedox BiologyFischer 344Oxidative StressElectron Microscopy +19

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Melanie S. Brennan, Hiral Patel, Norm Allaire, +8

Antioxidants and Redox Signaling

Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure

Julie H. Rennison, Tracy A McElfresh, Isidore C Okere, +10

Cardiovascular Research