Nick Knudsen

Optimized clinical performance of growth hormone with an expanded genetic code

Ho Cho, T. Sheidy Daniel, Ying J. Buechler et al. · Proceedings of the National Academy of Sciences · 2011 · 198 citations · Full text

Engineering, Medicinal Chemistry, Pharmacology +16

ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers

Lillian Skidmore, Sukumar Sakamuri, Nick Knudsen et al. · Molecular Cancer Therapeutics · 2020 · 160 citations

Pharmacy, Medicinal Chemistry, Oncology +17

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

Jeffrey C. Kern, Mark T. Cancilla, Deborah Dooney et al. · Journal of the American Chemical Society · 2016 · 141 citations

Pharmacy, Pharmaceutics, Pharmacology +17

In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates

Dowdy Jackson, John Atkinson, Claudia Guevara et al. · PLoS ONE · 2014 · 119 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs

Jeffrey C. Kern, Deborah Dooney, Rena Zhang et al. · Bioconjugate Chemistry · 2016 · 94 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17