Joe Patel

Potent and selective bivalent inhibitors of BET bromodomains

Michael J. Waring, Huawei Chen, Alfred A. Rabow et al. · Nature Chemical Biology · 2016 · 135 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury, Rowena Callis, Gregory R. Carr et al. · Journal of Medicinal Chemistry · 2016 · 86 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

Scott J. Eron, Hongwei Huang, Roman V. Agafonov et al. · ACS Chemical Biology · 2021 · 61 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

X. Guillory, M. Wolter, S. Leysen et al. · Journal of Medicinal Chemistry · 2020 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Jon Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin et al. · Journal of Medicinal Chemistry · 2022 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13