Jon Winter-Holt

Discovery of (2<i>R</i>)-<i>N</i>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<i>H</i>-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Qibin Su, Erica Banks, Geraldine Bebernitz et al. · Journal of Medicinal Chemistry · 2020 · 60 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Jon Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin et al. · Journal of Medicinal Chemistry · 2022 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

M. Raymond V. Finlay, Mark J. Anderton, Andrew Bailey et al. · Journal of Medicinal Chemistry · 2019 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy

William McCoull, Scott Boyd, Martin R. Brown et al. · Journal of Medicinal Chemistry · 2021 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +13

Generating Selective Leads for Mer Kinase Inhibitors—Example of a Comprehensive Lead-Generation Strategy

J. Willem M. Nissink, Sana Bazzaz, Carolyn Blackett et al. · Journal of Medicinal Chemistry · 2021 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16