Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets

Claire E. Knezevic, Gabriëla Wright, Lily L. Remsing Rix, +10

Cell chemical biology

Drug TargetMedicineBiomarker TargetProteomicsPathway Analysis +4

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Harshani R. Lawrence, Roberta Pireddu, Liwei Chen, +8

Journal of Medicinal Chemistry

GSK3 Alpha and Beta Are New Functionally Relevant Targets of Tivantinib in Lung Cancer Cells

Lily L. Remsing Rix, Brent M. Kuenzi, Yunting Luo, +8

ACS Chemical Biology

Chemoprevention StrategyImmunotherapeuticsCancer BiologyNovel Tivantinib TargetsReceptor Tyrosine Kinase +17

Effect of Ack1 tyrosine kinase inhibitor on ligand‐independent androgen receptor activity

Kiran Mahajan, Sridevi Challa, Domenico Coppola, +7

The Prostate

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Harshani R. Lawrence, Aslamuzzaman Kazi, Yunting Luo, +7

Bioorganic & Medicinal Chemistry

Proteasome InhibitorsBiochemistryMedicinePharmacotherapyNaphthoquinone Analogs +6

Development of <i>o</i>-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

Harshani R. Lawrence, Mathew P. Martin, Yunting Luo, +12

Journal of Medicinal Chemistry

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

Gabriëla Wright, Volha A. Golubeva, Lily L. Remsing Rix, +8

ACS Chemical Biology

Wee1 Tyrosine KinaseTumor BiologyWee1 Inhibitor Azd1775MedicineImmunology +13

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

Mathew P. Martin, J. Zhu, Harshani R. Lawrence, +7

ACS Chemical Biology

Protein AssemblyAurora AMolecular BiologyChemical BiologyProtein Folding +15

Development of Novel ACK1/TNK2 Inhibitors Using a Fragment-Based Approach

Harshani R. Lawrence, Kiran Mahajan, Yunting Luo, +8

Journal of Medicinal Chemistry

Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Yiyu Ge, Aslamuzzaman Kazi, Frank Marsilio, +7

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryProteasome InhibitorsBiochemistryMedicine +9