A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide

Wei Sheng, Xianghong Chen, Kathy Rocha, +11

Proceedings of the National Academy of Sciences

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

Xiaolei Zhang, Ying Sun, Roberta Pireddu, +6

Cancer Research

Novel InhibitorMolecular RegulationMolecular BiologyTranscriptional RegulationSignaling Pathway +14

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

Ronil A. Patel, Kara D. Forinash, Roberta Pireddu, +6

Cancer Research

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Harshani R. Lawrence, Roberta Pireddu, Liwei Chen, +8

Journal of Medicinal Chemistry

Development of <i>o</i>-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

Harshani R. Lawrence, Mathew P. Martin, Yunting Luo, +12

Journal of Medicinal Chemistry

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

Mathew P. Martin, J. Zhu, Harshani R. Lawrence, +7

ACS Chemical Biology

Protein AssemblyAurora AMolecular BiologyChemical BiologyProtein Folding +15

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

Rongshi Li, Mathew P. Martin, Yan Liu, +12

Journal of Medicinal Chemistry

Crystal StructureDrug TargetChemoprevention StrategyBiomolecular Structure PredictionCompound 18 +19

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Roberta Pireddu, Kara D. Forinash, Nan N. Sun, +8

MedChemComm

Medicinal ChemistryPyridylthiazole-based UreasDrug TargetBiochemistryNatural Sciences +13

Development of new N-arylbenzamides as STAT3 dimerization inhibitors

Murali K. Urlam, Roberta Pireddu, Yiyu Ge, +6

MedChemComm

Rb–Raf-1 Interaction Disruptor RRD-251 Induces Apoptosis in Metastatic Melanoma Cells and Synergizes with Dacarbazine

Sandeep Singh, Rebecca K. Davis, Vignesh Alamanda, +4

Molecular Cancer Therapeutics