Manuela Villa

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

Paola Vianello, Oronza A. Botrugno, Anna Cappa et al. · Journal of Medicinal Chemistry · 2015 · 81 citations · Full text

Histone Modifications, Novel Inhibitor, Epigenetic Change +17

Thieno[3,2-<i>b</i>]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration

Luca Sartori, Ciro Mercurio, Federica Amigoni et al. · Journal of Medicinal Chemistry · 2017 · 71 citations · Full text

Thieno[3,2-<i>b</i>]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship

Paola Vianello, Luca Sartori, Federica Amigoni et al. · Journal of Medicinal Chemistry · 2017 · 70 citations · Full text

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A

Paola Vianello, Oronza A. Botrugno, Anna Cappa et al. · European Journal of Medicinal Chemistry · 2014 · 54 citations · Full text

Biological Activity, Histone Demethylase Kdm1a, Natural Sciences +9

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A

Marco Pieroni, Giannamaria Annunziato, Elisa Azzali et al. · European Journal of Medicinal Chemistry · 2015 · 31 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +13