Laksshman Sundaram

Predicting the clinical impact of human mutation with deep neural networks

Laksshman Sundaram, Hong Gao, Samskruthi Reddy Padigepati et al. · Nature Genetics · 2018 · 502 citations · Full text

Deep Neural Networks, Engineering, Computational Medicine +8

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

Alexandro E. Trevino, Fabian Müller, Jimena Andersen et al. · Cell · 2021 · 491 citations

Chromatin, Developmental Biology, Chromatin Structure +12

The landscape of tolerated genetic variation in humans and primates

Hong Gao, Tobias Hamp, Jeffrey M. Ede et al. · Science · 2023 · 158 citations · Full text

Primatology, Genetics, Genetic Epidemiology +22

Identification of constrained sequence elements across 239 primate genomes

Lukas F. K. Kuderna, Jacob C. Ulirsch, Sabrina Mohd Rashid et al. · Nature · 2023 · 96 citations · Full text

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

Mohamed Ameen, Laksshman Sundaram, Mengcheng Shen et al. · Cell · 2022 · 94 citations · Full text

Cardiomyopathy, Developmental Biology, Cardiac Reprogramming +9