Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Pankajini Mallick, Marjory Moreau, Gina Song, +9

Toxicological Sciences

Internal DosePharmacotherapyIntrinsic ClearancePhysiologically-based Pharmacokinetic ModelingPharmacokinetics +15

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Rebecca A. Clewell, Bin Sun, Yeyejide Adeleye, +7

Toxicological Sciences

Dna DamageMolecular BiologyCell DeathToxicological MechanismP53 Activation +15

Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures

Melvin E. Andersen, George Cruzan, Michael B. Black, +7

Toxicology and Applied Pharmacology

MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells

Chad Deisenroth, Michael B. Black, Salil N. Pendse, +4

PLoS ONE

Myc TranscriptAdult Stem CellHuman AdipogenesisMetabolic RemodelingAdipokines +16

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for<i>PPARG</i>Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

Briana Foley, Daniel Doheny, Michael B. Black, +5

Toxicological Sciences

Metabolic DisorderMetabolic RemodelingStem Cell BiologyAdipokinesInsulin Signaling +21

Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates

Marjory Moreau, Jeremy A. Leonard, Katherine A. Phillips, +10

Chemosphere

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods

Patrick D. McMullen, Sudin Bhattacharya, Courtney G. Woods, +7

Toxicology in Vitro

Transcriptional RegulationHepatotoxicityQualitative DifferencesMetabolic SignalingPparα Specific Ligand +22

Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures

Patrick D. McMullen, Salil N. Pendse, Michael B. Black, +4

Toxicology in Vitro

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Salil N. Pendse, Alexandra Maertens, Michael Rosenberg, +11

Archives of Toxicology

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

Melvin E. Andersen, Michael B. Black, Jerry L. Campbell, +7

Toxicology and Applied Pharmacology