Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Clarissa Campbell, Peter T. McKenney, Daniel Konstantinovsky, +12

Nature

Signal TransductionBiliary TractT-regulatory CellImmunologyBacterial Metabolism +8

Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation

Mohammad Arifuzzaman, Tae Hyung Won, Tingting Li, +38

Nature

InflammationProbioticMicrobiota FunctionDysbiosisInulin Fibre +8

Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome

Wen‐Bing Jin, Tingting Li, Da Huo, +10

Cell

Microbiome BiologyDysbiosisHost-microbe InteractionsSingle-gene InterrogationGenetics +8

Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology

Tingting Li, Xi Chen, Da Huo, +8

Cell Host & Microbe

NutritionDysbiosisNutrient PhysiologyHost-microbe InteractionsMedicine +12

Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection

Wen Zhang, Mengze Lyu, Nicholas J. Bessman, +14

Cell

InflammationProbioticDysbiosisPhysiologyMicrobiota +10

Transferable Immunoglobulin A–Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation

Svetlana Lima, Lasha Gogokhia, Monica Viladomiu, +12

Gastroenterology

DysbiosisMucosal ImmunologyMicrobial PathogensMedicineImmunology +7

Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation

Monica Viladomiu, Maeva Metz, Svetlana Lima, +7

Cell Host & Microbe

InflammationChronic Inflammatory DiseasesIntestinal InflammationMicrobial PathogensCrohn ’ +6

Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression

Zhongchi Li, Vivien Low, Valbona Luga, +15

Nature Communications

Host metabolism balances microbial regulation of bile acid signalling

Tae Won, Mohammad Arifuzzaman, Christopher N. Parkhurst, +8

Nature

BiochemistryBiliary TractLiver PhysiologyGut-organ AxisBile Acid +5

A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis

Wen‐Bing Jin, Sheng Wu, Xiao‐Hong Jian, +2

Nature Communications