Jinxin Xu

Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity

Tingting Xu, Lu Liu, Shulin Hou et al. · Journal of Structural Biology · 2012 · 69 citations

Crystal Structure, Proteinlipid Interaction, Engineering +8

Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir

Xiaoxin Chen, Xiaodong Huang, Qinhai Ma et al. · Nature Microbiology · 2024 · 61 citations · Full text

Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

Na Wang, Qingan Zou, Jinxin Xu et al. · Journal of Biological Chemistry · 2018 · 56 citations · Full text

Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943

You Kure Wu, Tingting Xu, Jinsong Liu et al. · Biochemical and Biophysical Research Communications · 2017 · 40 citations

Drug Target, Biochemistry, Natural Sciences +8

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer

Yan Zhang, Xishan Wu, Xiaoqian Xue et al. · Journal of Medicinal Chemistry · 2019 · 38 citations · Full text