Jorge Guzman‐Lepe

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Kazuki Takeishi, Alexandra Collin de l’Hortet, Yang Wang et al. · Cell Reports · 2020 · 117 citations · Full text

Engineering, Bioengineering, Biotechnology +17

Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism

Alexandra Collin de l’Hortet, Kazuki Takeishi, Jorge Guzman‐Lepe et al. · Cell Metabolism · 2019 · 103 citations · Full text

Life Sciences, Biotechnology, Molecular Genetics +11

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids

Takamasa Tobita, Jorge Guzman‐Lepe, Kazuki Takeishi et al. · PLoS ONE · 2016 · 47 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks

Yang Wang, Kazuki Takeishi, Zhao Li et al. · Organogenesis · 2017 · 38 citations · Full text

Medicine, Cell Biology, Oncology +17

Liver‐enriched transcription factor expression relates to chronic hepatic failure in humans

Jorge Guzman‐Lepe, Eduardo Cervantes‐Alvarez, Alexandra Collin de l’Hortet et al. · Hepatology Communications · 2018 · 37 citations · Full text

Medicine, Molecular Biology, Molecular Genetics +12