A genetic selection for isolating cDNAs encoding secreted proteins

Kenneth Jacobs, Lisa A. Collins‐Racie, Maureen Colbert, +10

Gene

Protein SecretionGeneticsProtein GeneticsGenetic EngineeringProtein Evolution +5

Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss

Vincent Ling, Paul W. Wu, Vikki Spaulding, +4

Genomics

ImmunogeneticsAutoimmune DiseaseDivergent HistoryMedicineHumoral Response +9

Covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay

Christoph W. Zapf, Brian S. Gerstenberger, Xing Li, +12

Journal of Medicinal Chemistry

Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody

Jessica D. Weaver, Edward C. Stack, Joshua Buggé, +26

OncoImmunology

T-regulatory CellImmunologyImmunoeditingRegulatory T CellsImmunologic Mechanism +18

In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

Yulia Vugmeyster, Heath Guay, Pamela Szklut, +14

mAbs

hKSR-2 inhibits MEKK3-activated MAP kinase and NF-κB pathways in inflammation

Padma L. Channavajhala, Vikram Rao, Vikki Spaulding, +2

Biochemical and Biophysical Research Communications

InflammationInflammatory DiseaseImmune Cell DevelopmentImmune RegulationImmunology +6

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors

Seungil Han, Robert Czerwiński, Nicole Caspers, +24

Biochemical Journal

T-regulatory CellImmunologyKinase InhibitorsMolecular BiologyImmunologic Mechanism +21

Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

Yulia Vugmeyster, Scott W. Allen, Pamela Szklut, +10

Journal of Translational Medicine

[26] A genetic selection for isolating cDNA clones that encode signal peptides

Kenneth Jacobs, Lisa A. Collins‐Racie, Maureen Colbert, +11

Methods in enzymology on CD-ROM/Methods in enzymology

Natural SciencesGeneticsDirected EvolutionPeptide LibraryProtein Genetics +9