Norman Aubry

Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists

Steven R. LaPlante, Rebekah Carson, James Gillard et al. · Journal of Medicinal Chemistry · 2013 · 103 citations

Practical Nmr Assay, Pharmaceutical Science, Compound Aggregation +24

Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain

Steven R. LaPlante, Dale R. Cameron, Norman Aubry et al. · Journal of Biological Chemistry · 1999 · 75 citations · Full text

Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy

Steven R. LaPlante, Norman Aubry, Gordon T. Bolger et al. · Journal of Medicinal Chemistry · 2013 · 54 citations

Pharmaceutical Science, Pharmaceutical Research, Engineering +23

Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy

Steven R. LaPlante, Araz Jakalian, Norman Aubry et al. · Angewandte Chemie International Edition · 2004 · 52 citations

Viral Polymerase Structure, Molecular Biology, Mode Determination +19

Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease

Steven R. LaPlante, Herbert Nar, Christopher T. Lemke et al. · Journal of Medicinal Chemistry · 2013 · 49 citations

Drug Target, Molecular Biology, Antiviral Drug +22